Best Casinos in Biloxi, MS - Hard Rock Hotel & Casino, Palace Casino Resort, Scarlet Pearl Casino & Resort, IP Casino Resort Spa, Boomtown Casino Biloxi. Coming in second place for largest casino in Mississippi is Island View Casino Resort with gaming machines and 45 table games. This casino can be. Top Mississippi Casinos: See reviews and photos of casinos & gambling attractions in Mississippi on TripAdvisor. The resort also features plenty of space to rest when the gaming is finished for the day. New Hampshire lottery results. This story is part of Travel Tips. Log in Join My Trips Bookings Rental Inbox. The law restricts casinos to coast waters including the Bay of St. Mississippi casinos have not only added to the economy but gave a new name to tourism in the state. Discover Where to Stay. If the business you're looking for isn't here, add it! Sam's Town Casino Tunica. The Isle of Capri in Biloxi was the first casino to open on August 1, followed one month later by The President. Bally's Casino Tunica Tunica.